D1.9. Extended report on review and tests of methods for filling data gaps
D5.15. Program for a Training school on uncertainty
D5.16. Special training_session at the Joint INTARESE – HEIMTSA - 2-FUN Conference
Ciffroy, P. Uncertainty issues in 2-FUN. HEIMTSA – INTARESE – 2-FUN winter school. 2010, Firbush, UK.
Philippe Ciffroy, Elsa Casimiro. Uncertainty issues in 2-FUN. Presentation. HEIMTSA – INTARESE – 2-FUN Summer school. 2009. Stuttgart, Germany.
Giubilato E., Critto A., Micheletti C., Marcomini A., Bois F.Y. Full-chain and UNcertainty Approaches for Assessing Health Risks in FUture Environmental Scenarios: the 2-FUN project. (Poster, leaflets). 2007. INTARESE Project Annual Conference. 2007. Prague Czech Republic.
Fragoulis, G., Merl,i A., Reeves, G., Meregalli, G., Stenberg, K., Tanaka T., Capri, E. A Bayesian approach to assessing the uncertainty in estimating bioconcentration factors in earthworms – the example of quinoxyfen. Pest Manag Sci. 2011, 67: 0, doi 10.1002/ps.210.5 . IF: 2,19 (2009.)
Tanaka, T., Ciffroy, P., Stenberg, K., Capri, E. Regression approaches to derive generic and fish group-specific probability density functions of bioconcentration factors for heavy metals. Environmental Toxicology and Chemistry. 2010, vol. 29, no. 11, p. 2411-2425. IF: 2,656 (2009)
D1.4. Review and tests of methods for robust data treatment
D1.5. Definition of case studies for demonstrating the relevance of innovative methods for data treatment
D1.8. Definition and transfer selected methods for data treatment wia web platform, based on Open - Source platform (R-language)
D1.11. A set of scripts for learning the gnostic 1-dimensional and multidimensional advanced analysis
D1.12 Set of scripts for learning multidimensional gnostics
D1.12 GSCHOOL1
D1.12 GSCHOOL2
D1.12 GSCHOOL3
D1.12 GSCHOOL4
D1.12 GSCHOOL5
D1.13 Comparison of uncerainty methods
D5.13 Summer school on Gnostic Approach
Kovanic, P. and Ocelka, T. (IPH). Problems of intercalibration. IPSIC (International Passive Sampling Intercalibration). 2009. Prague, Czech Republic.
Kovanic, P., Ocelka, T. (IPH). Correlations in pollutants and toxicities. 3Rd Internationla Passive Sampling Workshop and Symposium. 2009. Prague, Czech Republic
Kovanic, P., Ocelka, T. (IPH). Correlations in pollutants and toxicities. 3Rd Internationla Passive Sampling Workshop and Symposium. 2009. Prague, Czech Republic
Elisa Giubilato, Antonio Marcomini, Elsa Casimiro, Pavel Kovanic.A taste of results from Work Package 1. Task1.3 (Institute of Public Health, Ostrava). Newsletter No. 7. 2010, p. 2-3.
Tomáš Ocelka, Pavel Kovanic, Olga Tomoszková. 2-FUN Summer school on Gnostic Approach to Small Sample Data Analysis.Newsletter No. 7. 2010, p. 3-5.
Pavel Kovanic. Puzzles of quantitative uncertainty. Newsletter No. 6. 2010, p. 6-7.
Pavel Kovanic. Mathematical Gnostics. Newsletter No. 4. 2009, P. 1-6.
Antonio Marcomini, Elisa Giubilato, Andrea Critto, Elsa Casimiro, Pavel Kovanic, Tomas Ocelka. 2-FUN: methodologies for the construction and selection ofrealistic scenarios.Task 1.3. Newsletter No. 3. 2008, p. 1.p. 4.
D1.6. Review of probabilistic methods and approaches to estimate integrated risk indices
D1.1. Critical review and selection of causality analysis approaches and tools
D1.10. Application and testing of methodology for ranking environmental stressors (Part 1 – Methodological Development)
D1.14. Application and testing of a methodology for ranking environmental stressors (Part II Testing application to a case study
D1.15. Estimation of Risk Indices for the Analysis of Uncertainty related to Scenario Characterization Uncertainty/Sensitivity Analysis for a MCDA Methodology for the Ranking of Environmental Chemical Stressors
Elisa Giubilato, Antonio Marcomini, Elsa Casimiro, Pavel Kovanic.A taste of results from Work Package 1. Task1.1 (University of Venice). Newsletter No. 7. 2010, p. 1-2.
Antonio Marcomini, Elisa Giubilato, Andrea Critto, Elsa Casimiro, Pavel Kovanic, Tomas Ocelka. 2-FUN: methodologies for the construction and selection of realistic scenarios. Task 1.1. Newsletter No. 3. 2008, p. 1.p. 3-4.
D1.2-I Methodologies for downscaling socio-economic, technological and emission scenarios, as well as meteorological scenario data, to country level and smaller regions. PART I: SOCIETY AND TECHNOLOGY
D1.2-II Methodologies for downscaling socio-economic, technological and emission scenarios, as well as meteorological scenario data, to country level and smaller regions. PART II: CLIMATE
D1.3. Preliminary database with future climate, emissions, and socio-economic data for case studies
D1.7. Final database for case study - R. Aguiar
Casimiro, E. Integrating Climate Change in Health Risk Assessments. ImpactE : International Conference on "Past, Present and Future Health Impacts of Extreme Events". 2009. Lisbon, Portugal.
Lopes, P. Local Scale Climate Change Scenarios. ImpactE : International Conference on "Past, Present and Future Health Impacts of Extreme Events". 2009. Lisbon. Portugal.
Lopes, P. Assessment of Climate Change Statistical Downscaling Methods. Seminar @ SIM. Uni. of Lisbon. 2009. Lisbon, Portugal.
Lopes, P. et al. Assessment of statistical downscaling methods – application and comparison of two statistical methods to a single site in Lisbon. The International Scientific Conference Copenhagen 2009 – Climate Change Global Risks, Challenges and Decisions. 2009. Copenhagen, Denmark.
Lopes, P. et al. Integration of climate change scenarios in air pollution models. CONCAWE Workshop on Environment & Health: Evaluating European Air Quality Research & Translating Priorities into Programmes. 2009. Brussels, Belgium.
Casimiro, E. et al. Intergrating climate change Scenarios into local air quality health risk assessment: a 2-FUN case study. CONCAWE Workshop on Environment & Health: Evaluating European Air Quality Research & Translating Priorities into Programmes. 2009. Brussels, Belgium.
Elisa Giubilato, Antonio Marcomini, Elsa Casimiro, Pavel Kovanic.A taste of results from Work Package 1. Task1.2 (Fundaçao da Faculdade de Ciencias da Universidade de Lisboa). Newsletter No. 7. 2010, p. 2.
Antonio Marcomini, Elisa Giubilato, Andrea Critto, Elsa Casimiro, Pavel Kovanic, Tomas Ocelka. 2-FUN : methodologies for the construction and selection ofrealistic scenarios.Task 1.2. Newsletter No. 3 2008, p.3-4.
D2.1. Proposal of the conceptual and mathematical 2-FUN model for assessing transfer of contaminants in freshwater and associated indirect exposures
D2.3. Intermediate database on transfer factors from air, water, soil to food for exposure of humans
D2.4. Proposal of the conceptual and mathematical 2-FUN model for assessing transfer of contaminants in plants and animals, and associated indirect exposures
D2.5. Review of features, events and processes incorporated in existing multimedia models for soil and groundwater. Proposal of the conceptual and mathematical 2-FUN model for assessing transfer of contaminants in soil and groundwater and associated indirect exposures
D2.6. Atmosphere multimedia models
D2.8. Database of parameters describing the transfer of contaminants in the environment
D5.22. User guide of the 2-FUN multimedia software
D2.9. Database of parameters describing the transfer of contaminants in the environment
D2.10. Age related regional food intake patterns for children in Europe
D2.11. 2-FUN software for end-users
D5.19. Internal training session on the 2 FUN multimedia software
Dimosthenis Sarigiannis, Alberto Gotti, Pedro Serpa, Elsa Casimiro, Erik Johansson. Environmental Health Risk Assessment of Ambient BTEX Levels in Lisbon, Portugal: A PBPK Study Approach. (Poster presented on the INTARESE, HEIMTSA, 2-FUN Final Annual Meeting “Concepts and Tools for Integrated Environmental and Health Impact Assessment (IEHIA), Brussels).
Legind, C. N. & Trapp, S. Modelling the indirect human exposure to chemicals in soil and air with crop-specific models. SETAC Europe 19th Annual Meeting. 2009. Göteborg, Sweden.
Franco, A., Fu, W., Trapp, S. Adapting environmental fate models to ionizable compounds. SETAC Europe 18th Annual Meeting. 2008. Warsaw, Poland.
Trapp, S. and Legind, C. N. Uptake of Organic Contaminants from Soil into Vegetables and Fruits. In: Frank Swartjes, ed. Dealing with contaminated sites. Springer: 2011. p. 369-408.
Legind, C. N, Trapp, S. Comparison of prediction methods for the uptake of As, Cd and Pb in carrot and lettuce. SAR/QSAR Env. Res. 2010, vol. 21, no. 5-6, p. 513-525 (DOI: 10.1080/ 1062936X.2010.502296). IF: 1,682 (2009).
Ciffroy, P., Tanaka, T., Johansson, E., Brochot, C. Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated to drinking water. Environmental Geochemistry and Health (DOI: 10.1007/s10653-011-9382-6 Online First). IF: 1,622 (2009).
Erik Johansson. Developing the 2-FUN multimedia software. Newsletter No. 6. 2010, p. 1-4.
Tanaka, T., Ciffroy, P., Stenberg, K., Capri, E. Regression approaches to derive generic and fish group-specific probability density functions of bioconcentration factors for metals. Environmental Toxicology and Chemistry DOI: 10.1002/etc.295. IF 2, 565 (2009).
Trapp, Stefan. Bioaccumulation of polar and ionizable compounds in plants. In Devillers, James (ed.). Ecotoxicology Modelling. Dordrecht: Springer, 2009. p.299-353. ISBN 978-1-4419-0196-5 (Print), e-ISBN 978-1-4419-0197-2.
Legind, C. N. & Trapp, S. Modeling the exposure of children and adults via diet to chemicals in the environ¬ment with crop-specific models. Environ Pollution. 2009, vol.157, no. 3, p. 778-785.IF: 3, 426 (2008)
Franco, A., Trapp, S. Estimation of the soil-water partition coefficient normalized to organic carbon for ionizable organic chemicals. Environmental Toxicology and Chemistry. 2008, vol. 27, no. 10, p. 1995-2005. IF: 2, 309 (2007)
Fu, Huijin Modelling theuptake of organic chemicals by adults and children. Master thesis. 2008.
Trapp S., Cammarano A, Capri E., Reichenberg F., Mayer P. Diffusion of PAH in Potato and Carrot Slices and Application for a Potato Model. Environ. Sci. Technol., 2007, 41(9):3103, IF 4,04.
D3.2. Demonstrator for the methodology, with the coupling of PBPK and pathology models
D3.5. PBPK/PD model for atrazine and arsenic
D3.6. A database for PK parameters with information on the inter-individual variability
D3.7. A database for PK parameters with information on the inter-individual variability
D3.10. Coupling the metabolic reaction network with a PBPK model application to the BTEX mixture
D5.18. Training session on Physiologically based pharmacokinetic models
Dimosthenis Sarigiannis, Alberto Gotti, Pedro Serpa, Elsa Casimiro, Erik Johansson. Environmental Health Risk Assessment of Ambient BTEX Levels in Lisbon, Portugal: A PBPK Study Approach. (Poster presented on the INTARESE, HEIMTSA, 2-FUN Final Annual Meeting “Concepts and Tools for Integrated Environmental and Health Impact Assessment (IEHIA), Brussels).
Bois, F.Y. Systems Biology PBPK Modelling of Metabolit Interactions.(Poster) VII.World Congress on Alternatives and Animals use in Life Science. 2009. Rome, Italy.
Bois, F.Y. Using Biomonitoring Data to Improve Advanced Risk Assessment. European Conference on Human Biomonitoring. 2008. Paris, France.
Beaudouin, R., Micallef, S., Brochot, C. A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan. Regulatory Toxicology and Pharmacology. 2010, vol. 57. no. 1, p. 103-116. IF 1, 798 (2009).
Frederic Y. Bois. SBML assisted physiologically based pharmacokinetic modelling of metabolic interactions. Newsletter No. 4. 2009, p. 7-11.
Trapp, S., Ma, L., Legind,C.N. Coupled mother-child model for the bioaccumulation of POPs in nursing infants. Environ Pollut. 2008, vol.156, no. 1, p. 90-98. IF: 3,135 (2007).
D3.3. Detailed description of methods, models, and model selection procedures, for QSAR predictions for toxicokinetic properties of chemicals
D3.4. Prototype of the property estimation and database software
D3.5. New QSAR model to estimate the blood/air partition coefficient
D3.8. New QSAR model to estimate the fat/air partition coefficient
D3.9. Pathology models for chemicals and mixtures
Kühne, R., Ebert, R-U., Schüürmann, G. Atom-centred fragments in QSAR Modelling. P. Sil P7.12th International Conference on Chemistry and the Environment. 2009. Stockholm, Sweden.
Thalheim T., Kühne, R., Ebert, R.R, Schüürmann, G. Effect of Different Tautomers on QSAR Models: Comparison between Several Levels of Tautomer Recognition. P. Sil P8. 12th International Conference on Chemistry and the Environment. 2009. Stockholm, Sweden.
Stöckl, S., Kühne, R., Ebert, R.-U., Schüürmann, G. Prediction of the partition coefficient between air and body compartments from the chemical structure. P. Sil P10.
12th International Conference on Chemistry and the Environment. 2009. Stockholm, Sweden.
Thalheim, T., Kühne, R. Ebert, R.-U., Schüürmann, G. Impact of heteroatom tautomers on QSAR models. SETAC Europe 19th Annual Meeting. 2009. Göteborg, Sweden.
Thalheim, T., Kühne, R., Ebert, R.-U., Schüürmann, G. Effect of different tautomers on QSAR models: Comparison between several levels of tautomer recognition. SETAC Europe 19th Annual Meeting. 2009. Göteborg, Sweden.
Kühne, R., Thalheim, T., Ebert, R.U., Vollmer, A., Schüürmann, G. Chemical complexity mapping in QSAR models. 4. German Conference on Chemoinformatics. 22. CIC-Workshop. 9-11 November 2008.
Kühne, R., Thalheim, T., Ebert, R.U., Vollmer, A., Schüürmann, G. Chemical complexity mapping in QSAR models. (Poster). 13th International Workshop on Quantitative Structure-Activity Relationships (QSARs) in the Environmental Sciences. 2008. Syracuse, USA
Kühne, R., Thalheim, T., Ebert, R.U., Vollmer, A., Schüürmann, G. Chemical complexity mapping in QSAR models. (Poster). SETAC Europe 18th Annual Meeting. 2008. Warsaw, Poland.
Thalheim, T., Vollmer, A., Ebert, R-U., Kühne, R., Schüürmann, G. Tautomer identification and tautomer structure generation based on the InChI code. J. Chem. Inf. Model. 2010, vol. 50, no. 7, p. 1223–1232. IF: 3,882(2009).
Ralph Kühne, Ralf-Uwe Ebert, Gerrit Schüürmann. Chemical Domain of QSAR Models from Atom-Centred Fragments. Newsletter No. 6. 2010, p. 4-5.
Thalheim, T., Vollmer, A., Ebert R.-U., Kühne, R, Schüürmann, G. Tautomer identification and tautomer structure generation based on the InChI code. J. Chem. Inf. Model. 2010, vol. 50, no. 7, p. 1223-1232. IF 3.882(2009).
Kühne R., Ebert R.-U., Schüürmann, G. (UFZ) Chemical domain of QSAR models from atom-centered fragments. J. Chem. Inf. Model. 2009, vol.49, no.12, p. 2660-2669. IF 3,64(2008).
D3.1. Detailed description of the general PBPK model, describing metabolic interactions
Bois, F.Y. Systems Biology PBPK Modelling of Metabolic Interactions.(Poster) VII.World Congress on Alternatives and Animals use in Life Science. 2009. Rome, Italy.
Bois F.Y. Physiologically-based modelling and prediction of drug interactions. Basic and Clinical Pharmacology and Toxicology. 2010, vol. 106, no. 3, March 2010, p. 154-161. IF 2,073 (2009).
Bois F.Y. Physiological modelling of metabolic interactions. Environnement, Risque et Santé. 2009, vol. 8, no. 5, p. 413-424.
Bois, F.Y. GNU MCSim: Bayesian statistical inference for SBML-coded systems biology models. Bioinformatics. 2009, Mar 20. vol. 25, no. 11, p. 1453-1454. IF: 5.039 (2008).
Sarigiannis, D. A., Gotti, A. (JRC). Biology-based models for health risk assessment of chemical mixtures, Fresenius Environmental Bulletin. 2008, vol. 17, no. 9b. (peer-reviewed).
D2.2. Review of relevant exposure pathways for children and parameterisation for their introduction in multi-media models
D2.7. Parameterisation of relevant exposure pathways for children
D2.10. Age related regional food intake patterns for children in Europe
Johan Bierkens, Christa Cornelis, Mirja van Holderbeke and Rudi Torfs Children’s characteristics influencing exposure. 18th SRA-Europe Annual Meeting - From the everyday to the extraordinary: challenges for risk analysis and management. 2009. Karlstad, Sweden.
J. Bierkens, C. Cornelis, M. van Holderbeke and R. Torfs. Inventarisation and parameterisation of child-specific exposure factors. SETAC Europe 19th Annual Meeting. 2009. Göteborg, Sweden.
Bubak, A., Gzyl, J., Kulka, E. Preliminary analysis of children's environmental exposure to lead, cadmium and PAHs in the Upper Silesia region in 2008 (2-FUN project). IX Conference of Polish Society of Toxicology. 2008. Warsaw, Poland.
Johan Bierkens. Parameterisation of children exposure to environmental pollutants. Newsletter No. 5. 2009, p. 1-5.
Charlotte N. Legind and Stefan Trapp. Exposure to BaP via diet for children and adults. Newsletter No. 5. 2009, p. 5-6.
D4.1. Specifications for the development of methodologies / databases/software relevant for the respective case studies
D4.2. Critical analysis of previous studies related to the case studiesand internal collection of datasets for further use in the case studies
D4.6. Time-series models on acute health impacts of air pollution and heatstress in Lisbon
D4.7. Health effects from ambient BTEX exposure Case study 1 : intermediate report
D4.8. Health effects from exposures to ambient pollution and thermal stress in Lisbon : Case study 1 Final report
Dimosthenis Sarigiannis, Alberto Gotti, Pedro Serpa, Elsa Casimiro, Erik Johansson. Environmental Health Risk Assessment of Ambient BTEX Levels in Lisbon, Portugal: A PBPK Study Approach. (Poster presented on the INTARESE, HEIMTSA, 2-FUN Final Annual Meeting “Concepts and Tools for Integrated Environmental and Health Impact Assessment (IEHIA), Brussels).
Almeida, S., Casimiro, E., Calheiros, J. (FFCUL) Effects of Apparent Temperature on Daily Mortality in Lisbon and Oporto. Environmental Health. 2010, March 2010, vol. 9, no. 12, p./rec. no. 12. IF 2,48 (2009).
Almeida, S., Casimiro, E., Calheiros, J. Effects of Apparent Temperature on Daily Mortality in Lisbon and Oporto. Environmental Health. 2010, March 2010, vol. 9, no. 12. IF 2,48 (2009).
Elsa Casimiro. Case study 1: Evolution of air pollutants and thermal stress in Portugal and implications for future health risk. Newsletter No. 3. 2008, p. 1.
D4.4. Intermediate case study using the exposure freshwater model
D4.9. Case study 2 Seine river watershed France : Final report
Ciffroy, P., Tanaka, T., Johansson, E., Brochot, C. Linking multimedia environmental and PBPK models to assess health risks of B(a)P associated to drinking water – a case study. SEGH 2010 - Environmental Quality and Human Health. Galway, Ireland, June 27 - July 2, 2010.
Philippe Ciffroy. Case study 2: Choices of industrial technologies to minimise the impact of the industrial and agricultural activities on population health at the level of a river watershed in France. Newsletter No. 3. 2008, p. 2.
D4.3. Relationships between environmental exposure and health outcomes based on CS3 case study
D4.5. Draft of final case study (CS3) results using the exposure model related to children
Budziñska, M., Bubak, A., Gzyl, J. Analiza mo¿liwych skutków zdrowotnych w zwi¹zku ze œrodowiskowym nara¿eniem na o³ów, kadm i wielopierœcieniowe wêglowodory aromatyczne u dzieci z województwa œl¹skiego w latach 1999-2007, Projekt 2-FUN (Analysis of possible health outcomes related to environmental exposure to lead, cadmium and polycyclic aromatic hydrocarbons for children from Silesian Voivodeship in 1999-2007, 2-FUN project). National conference “Zdrowie w XXI wieku a promocja zdrowia” (Health of XXI century and Health promotion). 2009. Warsaw, Poland.
Bubak, A. (IETU). Full-change and uncertainty approaches for assesssing health risks in future environmental scenarios – the status of work in the project 2-FUN. Meeting of Silesian Branch of Polish Society of Environmental Medicine. 2008. Katowice, Poland.
Anicenta Bubak. Health outcomes concerning children's environmental exposure to soil contaminants lead, cadmium and polycyclic aromatic hydrocarbons. Newsletter No. 5. 2009, p. 6-8.
Jadwiga Gzyl. Case Study 3: Health risk assessment for children living in the industrial area of Upper Silesia in Poland. Newsletter No. 3. 2008, p. 2-3.
